I know everything I am looking for is here, watch movies, watch series, education, games, exams, news, current events and many more.
“#How turning back the clock in aging fat cells can be a remedy for lifestyle diseases” Figure 1: Rubicon levels in mouse adipose tissue decrease with age. (Mouse adipose tissue) The abundance of Rubicon in adipose tissue from 25-month-old mice was significantly decreased compared with that of 3-month-old mice. Levels of an autophagic substrate, p62,…
“#Researchers discover how enzyme protects cells from DNA damage” Credit: CC0 Public Domain A research team from Mount Sinai has unraveled for the first time the three-dimensional structure and mechanism of a complex enzyme that protects cells from constant DNA damage, opening the door to discovery of new therapeutics for the treatment of chemotherapy-resistant cancers….
“#Bio-based communication networks could control cells in the body to treat conditions” Credit: CC0 Public Domain Like electronic devices, biological cells send and receive messages, but they communicate through very different mechanisms. Now, scientists report progress on tiny communication networks that overcome this language barrier, allowing electronics to eavesdrop on cells and alter their behavior—and…
“#New guidelines for phage preparation can accelerate lifesaving treatment” San Diego State University microbiologist Dwayne Roach’s phage lab has developed new guidelines to prepare phage that will accelerate the time to therapy while streamlining the process. Credit: SDSU Roach Lab When clinicians resort to phage therapy for patients who don’t respond to antibiotics, the patients…
“#The search for molecular glue in targeted disease control” On the left is the signal molecule that acts as an inhibitor, preventing other proteins from binding. On the right, the signal molecule that acts as a stabilizer, strengthening the binding of the protein complex. The researchers were able to convert the signal molecule in such…
“#Why does COVID-19 impact only some organs, not others?” An interaction map of the main disease activators for SARS-CoV-2 in the lungs and how they impact proteins in other organs. Credit: Ernesto Estrada In severe cases of COVID-19, damage can spread beyond the lungs and into other organs, such as the heart, liver, kidney and…
“#Scientists introduce Raman-activated cell sorter for high-throughput discovery of enzymes” Schematic illustration of the FlowRACS platform and instrument. Credit: WANG Xixian Enzymes are molecules that catalyze metabolism. Discovering and mining enzymes, such as those producing oils or fixing carbon dioxide, have been a key mission of the biotechnology industry. However, this can be very slow…
“#Molecular forces: The surprising stretching behavior of DNA” Johannes Kalliauer. Credit: Vienna University of Technology When large forces act on a heavy beam, for example, in bridge construction, the beam will be slightly deformed. Calculating the relationship between forces, internal stresses and deformations is one of the standard tasks in civil engineering. But what happens…
“#Computer-aided systems may speed up new anticancer drug development” A workflow for drug discovery: from target identification to drug approval. Credit: SIAT New drug discovery is a complicated, expensive and time-consuming process. Traditional drug development pipeline needs 12 years and $2.7 billion USD on average. Reducing research costs and speeding up development processes of new…
“#In defence mode: This is how Zika virus protects key parts of its genome” Credit: International School of Advanced Studies (SISSA) To fight viruses, cells can deploy defense enzymes that progressively destroy viral genome strands starting from one of the two strand ends. However, this degradation mechanism is not effective against epidemic viruses such as…