#Scientists expose fascinating ‘compartments’ in bacteria

“#Scientists expose fascinating ‘compartments’ in bacteria” Credit: CC0 Public Domain Bacteria—tiny and in some cases deadly single-celled organisms—are far more complex than commonly thought. A review paper by Monash Biomedicine Discovery Institute (BDI), published in the high-impact journal Nature Reviews Microbiology, casts light on organelles, the internal compartments in bacterial cells that house and support…

Read More

#Scientists find new way to kill tuberculosis

“#Scientists find new way to kill tuberculosis” Surface electrostatic representation of toxin MenT (blue, positive; red, negative), showing where target tRNA would bind and the enzymatic active site. Credit: Ben Usher, Dr Tim Blower. The toxin can block the use of important amino acids required by the bacteria to produce essential proteins needed for survival….

Read More

#Analyzing chromatin status of poised genes may provide powerful tool to predict transcription potential

“#Analyzing chromatin status of poised genes may provide powerful tool to predict transcription potential” Model for the prediction of gene expression potential through identifying the local chromatin states. Credit: Dr. LI Guohong’s group In eukaryotic cells, the genomic DNA is hierarchically packaged by histones into chromatin. Chromatin structure and its plasticity play an important role…

Read More

#Identification of new ‘oxidative stress sensor’ MTK1

“#Identification of new ‘oxidative stress sensor’ MTK1” Oxidative stress-induced MTK1 activation requires both oxidation and reduction of MTK1. Cells were treated with H2O2 for the indicated times. Cell extracts were electrophoresed under non-reducing conditions and immunoblotted with an anti-Myc antibody (top).  Immunoprecipitated Myc-MTK1 was electrophoresed under reducing conditions and probed with anti-P-MTK1 or anti-Myc antibodies…

Read More

#Medieval medicine remedy could provide new treatment for modern day infections

“#Medieval medicine remedy could provide new treatment for modern day infections” The Balds Eyesalve mixture in the lab. Credit: University of Warwick Antibiotic resistance is an increasing battle for scientists to overcome, as more antimicrobials are urgently needed to treat biofilm-associated infections. However scientists from the School of Life Sciences at the University of Warwick…

Read More

#New study reveals how day- and night-biting mosquitoes respond differently to colors of light and time of day

“#New study reveals how day- and night-biting mosquitoes respond differently to colors of light and time of day” Credit: Pixabay/CC0 Public Domain In a new study, researchers found that night- versus day-biting species of mosquitoes are behaviorally attracted and repelled by different colors of light at different times of day. Mosquitoes are among major disease…

Read More

#Video: Single cells have their own defenses against pathogens

“#Video: Single cells have their own defenses against pathogens” Credit: CC0 Public Domain In the fight against pathogens, most researchers have focused on the diverse immune system arsenal that protects people against infection. However, the lab of Yale microbiologist Jorge Galan explored an evolutionarily ancient defense system possessed by every individual cell in the body….

Read More

#Phage therapy shows potential for treating prosthetic joint infections

“#Phage therapy shows potential for treating prosthetic joint infections” Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. The findings suggest phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes. The research is published in…

Read More

#New CRISPR DNA base editor expands the landscape of precision genome editing

“#New CRISPR DNA base editor expands the landscape of precision genome editing” Credit: CC0 Public Domain New genome-editing technologies developed by researchers in J. Keith Joung’s laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes. The new…

Read More