Biotechnology Molecular & Computational biology – Page 4

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#Deep learning on cell signaling networks establishes AI for single-cell biology

Admin6 years ago010 mins

“#Deep learning on cell signaling networks establishes AI for single-cell biology” by CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences </p><div> <div> <div data-src=”https://scx2.b-cdn.net/gfx/news/hires/2020/20-deeplearning.jpg” data-sub-html=”Conceptual outline of knowledge-primed neural networks (KPNNs). KPNNs are artificial neural networks whose structure is based on biological knowledge, thereby enabling interpretable deep learning on biological networks….

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#AI and single-cell genomics: New software predicts cell fate

Admin6 years ago06 mins

“#AI and single-cell genomics: New software predicts cell fate” scVelo reveals fine-grained insights into the developmental processes in the pancreas. Credit: Helmholtz Zentrum München Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions—but they do this with static snapshots only rather than time-lapse films. This limitation makes it difficult to draw…

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#Scientists discover ancient enzymes evolve new tricks

Admin6 years ago09 mins

“#Scientists discover ancient enzymes evolve new tricks” The green fluorescent protein reveals the exquisitely specific tomato hair cell expression of a gene for acylsugar biosynthesis. Credit: Pengxiang Fan Plants, herbivores, and pathogens are locked in a war for survival that is hundreds of millions of years old. Rooted in place and with no way to…

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#New understanding of CRISPR-Cas9 tool could improve gene editing

Admin6 years ago011 mins

“#New understanding of CRISPR-Cas9 tool could improve gene editing” The 3D structure of a base editor, comprised of the Cas9 protein (white and gray), which binds to a DNA target (teal and blue helix) complementary to the RNA guide (purple), and the deaminase proteins (red and pink), which switch out one nucleotide for another. Credit:…

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#Researchers discover a new and unique class of carbohydrate receptors

Admin6 years ago05 mins

“#Researchers discover a new and unique class of carbohydrate receptors” The determination of the crystal structure of an exopolysaccharide receptor gives insight into how plants and microbes communicate and this knowledge can hopefully be used for more sustainable agriculture where microbes have an important role. Credit: Kasper Røjkjær Andersen An international team of researchers led…

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#First gene knockout in cephalopod achieved

Admin6 years ago07 mins

“#First gene knockout in cephalopod achieved” Longfin inshore squid (Doryteuthis pealeii) hatchlings. On the left is a control hatchling; note the black and reddish brown chromatophores evenly placed across its mantle, head and tentacles. In contrast, the embryo on the right was injected with CRISPR-Cas9 targeting a pigmentation gene (Tryptophan 2,3 Dioxygenase) before the first…

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#New maps of chemical marks on DNA pinpoint regions relevant to many developmental diseases

Admin6 years ago010 mins

“#New maps of chemical marks on DNA pinpoint regions relevant to many developmental diseases” Credit: CC0 Public Domain In research that aims to illuminate the causes of human developmental disorders, Salk scientists have generated 168 new maps of chemical marks on strands of DNA—called methylation—in developing mice. The data, published July 29, 2020, in a…

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#Scientists discover the mechanism of competition between mitochondrial genomes coexisting

Admin6 years ago08 mins

“#Scientists discover the mechanism of competition between mitochondrial genomes coexisting” Left: Control cells with only the C57 mtDNA variant. Center: Heteroplasmic cells, containing C57 and NZB mtDNA variants in the cytoplasm. Right: Heteroplasmic cells treated with an activator of P-ERK, which restores the normal distribution and quantity of mitochondria. Credit: CNIC Research at the Centro…

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#ENCODE consortium identifies RNA sequences that are involved in regulating gene expression

Admin6 years ago011 mins

“#ENCODE consortium identifies RNA sequences that are involved in regulating gene expression” A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ Wikipedia The human genome contains about 20,000 protein-coding genes, but the…

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#ENCODE3: Interpreting the human and mouse genomes

Admin6 years ago06 mins

“#ENCODE3: Interpreting the human and mouse genomes” Logo for the ongoing ENCODE project (Encyclopedia of DNA Elements). Credit: ENCODE Scientists around the world have access to a rich trove of information through the Encyclopedia of DNA Elements (ENCODE)—annotated versions of the human and mouse genomes that are vital for interpreting their genetic codes. In the…