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“#Researchers map mechanisms in the largest CRISPR system” CRISPR-associated protein Cas9 (white) from Staphylococcus aureus based on Protein Database ID 5AXW. Credit: Thomas Splettstoesser (Wikipedia, CC BY-SA 4.0) The largest and most complex CRISPR system has been visualized by researchers from the University of Copenhagen in a new study. The system may have potential applications…
“#Black swan genome could be our secret weapon to combat next pandemic” Credit: CC0 Public Domain Scientists have mapped the genome of the black swan in an effort to understand immune responses to the deadly ‘bird flu’ virus and better protect public health. The University of Queensland team, led by Dr. Kirsty Short and Ph.D….
“#Exposure to enzymes causes peculiar response in liquid droplets formed by DNA; new study explains mechanisms behind it” Credit: courtesy image “A watched pot never boils,” as the saying goes, but that was not the case for UC Santa Barbara researchers watching a “pot” of liquids formed from DNA. In fact, the opposite happened. With…
“#New affinity purification technique for therapeutic proteins” Diagram of new protein therapeutics purification method using molecular affinity principle. Credit: Kimoon Kim (POSTECH) Professor Kimoon Kim’s research group at POSTECH has developed a highly pure and efficient technique for purifying antiviral and anti-cancer protein therapeutics using molecular affinity interaction. With COVID-19 showing no signs of slowing…
“#Researchers develop new cytosine base editors with high specificity and precision” Top: Rationally-designed APOBEC3B deaminases. Middle: Evaluation of the specificity of CBEs by the orthogonal R-loop assay. Bottom: Evaluation of the specificity of CBEs by whole genome sequencing. Credit: IGDB Base editors, which enable production of highly efficient targeted point mutations in genomic DNA without…
“#RNA biology provides the key to cell identity and health” A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ Wikipedia Two papers in Genome Research by the FANTOM Consortium have provided new…
“#European and American maize: Same same, but different” Metaphase chromosomes of maize after fluorescence in situ hybridization (FISH) with probes recognizing different types of repeats (in purple, green and yellow). Credit: Picture : A. Ruban and A. Houben, IPK, Gatersleben German researchers decoded the European maize genome. In comparison to North American maize lines, they…
“#New genome mapper is like ‘upgrading from dial-up to fibre-optic’” Pictures is the same cell nucleus visualised with conventional fluorescence image (DAPI) compared to with OligoFISSEQ for a 129 different loci. Credit: Marc Marti-Renom Researchers from Harvard University, the Centro Nacional de Análisis Genómico (CNAG) and the Center for Genomic Regulation (CRG) have described the…
“#A comprehensive description of the human tissue virome in healthy individuals” Human tissue virome atlas. By using SHIROKANE, a super computer in IMSUT, the research group detected 39 viral species in 51 tissues from 547 individuals in at least one tissue. Representative viruses detected are shown. The positive rate for each virus in each human…
“#New research reveals antifungal symbiotic peptide in legume” A peptide-based antifungal agent (three-dimensional structure shown in the upper right corner), when fluorescently labeled with red dye and visualized using confocal-microscopy, becomes dispersed in the cytoplasm and accumulates in the nucleolus of a common plant fungal pathogen, Botrytis cinerea. Calcofuor white (cyan) was used to stain…